Cyclosporin a CAS: 59865-13-3

Product Name:    Cyclosporin A    
CAS:59865-13-3
Molecular formula::C62H111N11O12
Molecular mass::1202.61
EINECS:611-907-1

Quantity:    46.8KG    
Man. Date:    2023-01-04
Packaging:    3KG/Tin    
Expiry Date:    2024-01-03
Appearance:    White or off-white powder    
Identification:    HPLC
Heavy metals:    ≤20ppm    <20ppm
Related substances:  Max single impurity≤0.7%
Total impurities:  ≤1.5%    
Appearance of solution:    The solution is clear and not moreintensely colored than reference solution Y5, BY5 or R7    
Loss on drying:    ≤2.0%    0.6%
Residual solvent:  ≤1000ppm
Petrolrumether:  ≤1000ppm    
Microbiological limits:     Total aerobes count ≤2000CFU/g
Moulds and yeasts: ≤200CFU/g
Escherichia Coli: Negative    
Assay:    97.0%~101.5% (on anhydrous)    98.2%
Conclusion:   Complies with Enterprise standard.
Storage:  Preserve in tight, light-resistant containers. Store at a temperature below 25ºC(allowing range of 15ºC to30ºC)

Properties: white or almost white powder, odorless and tasteless.  ethanol or acetonitrile, 
soluble in ethyl acetate, and almost insoluble in water. Specific rotation: take this product, 
weigh it precisely, and make a solution containing 10mg per 1ml. According to the law, 
the specific rotation is - 182 ° To - 192 ° Purpose: biochemical research. Inhibition of T cell receptor signaling pathway

New immunosuppressants. It is a cyclic polypeptide composed of eleven amino acids. 
It inhibits the immune function of humoral and cellular transmission, 
but does not inhibit bone marrow, and does not reduce the number of white blood cells. 
It can prevent rejection of transplanted tissue or organ. It is used in kidney transplantation, 
liver, lung transplantation and heart transplantation, and it also has certain curative effects on autoimmune diseases, 
schistosomiasis, malaria, diabetes, AIDS, and anti-inflammatory performance.