Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. Diphenhydramine is also used to relieve cough caused by minor throat or airway irritation. Diphenhydramine is also used to prevent and treat motion sickness, and to treat insomnia (difficulty falling asleep or staying asleep). Diphenhydramine is also used to control abnormal movements in people who have early stage parkinsonian syndrome (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) or who are experiencing movement problems as a side effect of a medication.
Diphenhydramine will relieve the symptoms of these conditions but will not treat the cause of the symptoms or speed recovery. Diphenhydramine should not be used to cause sleepiness in children. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Diphenhydramine is an antihistamine medication mainly used to treat allergies.It can also be used for insomnia, symptoms of the common cold, tremor in parkinsonism, and nausea. It is taken by mouth, injected into a vein, injected into a muscle, or applied to the skin.Max effect is typically around two hours after a dose, and effects can last for up to seven hours.
Tests | Standards | Results |
Appearance | White or almost white ,crystalline powder. | White,crystalline powder. |
Identification | A:IR absorption | Complies |
B:UV absorption | Complies | |
C:TLC | Complies | |
Melting point | 168~172°C | 169.0~170.9°C |
Water | Not more than0.5% | 0.08% |
Related substance | ImpurityJ(chloroacetanilide)not more than 10 ppm | 2ppm |
Impurity K not more than 50 ppm | 15 ppm | |
Impurity F not more than 0.05% | Not detected | |
any other impurity not more than 0.05% | 0.01% | |
Total of other impurities not more than 0.1% | 0.02% | |
Residue on ignition | Not more than 0.1% | 0.05% |
Chloride | Not more than 0.014% | Less than 0.014% |
Sulfate | Not more than 0.02% | Less than 0.02% |
Sulfide | Conforms | Conforms |
Heavy metals | Not more than 0.001% | Less than 0.001% |
Free p-aminophenol | Not more than 0.005% | Less than 0.005% |
Limit of P-chloroacetanilide | Not more than 0.001% | Less than 0.001% |
Readily carbonizable substances | Conforms | Conforms |
Residual solvents | Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5% | 0.08% |
Assay(anhydrous basis) | 99.0~101.0% | 99.6% |
Conclusion: Complies with USP34/ BP2011 |
Product Name | CAS No. | Molecular Formula |
Acetaminophen/Paracetamol | 103-90-2 | Analgesics |
Acetylsalicylic acid/Aspirin | 50-78-2 | Analgesics |
Chlorogenic acid | 327-97-9 | Analgesics |
Salicylamide | 65-45-2 | Analgesics |
Antipyrine | 60-80-0 | Analgesics |
Diclofenac sodium | 15307-79-6 | Analgesics |
Ibuprofen | 15687-27-1 | Anti-inflammation |
Ketoprofen | 22071-15-4 | Anti-inflammation |
Flurbiprofen | 5104-49-4 | Anti-inflammation |
(S)-Flurbiprofen | 51543-39-6 | Anti-inflammation |
Naproxen | 22204-53-1 | Anti-inflammation |
Naproxen Sodium | 26159-34-2 | Anti-inflammation |
Celecoxib | 169590-42-5 | Anti-inflammation |
Etoricoxib | 202409-33-4 | Anti-inflammation |
Piroxicam | 36322-90-4 | Anti-inflammation |
Nimesulide | 51803-78-2 | Anti-inflammation |
Meloxicam | 71125-38-7 | Anti-inflammation |