China GMP Factory Direct Supply 99% Purity Buy a-Icar Acadesine Raw Powder CAS 2627 -69-2

Colour
White
Shipment Time
Within 24 Hours After Payment Is Recieved
Policy
Reshipment
Grade
Medicine Grade
Purity
99%
Transport Package
Discreet and Disguised
Specification
Qualified
Trademark
WHOK
Origin
China
HS Code
3001200020
Production Capacity
50 Mt/Year
Reference Price
$ 9.00 - 45.00
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Product Description

Product Description

Chemical Name: 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (A-ICAR for short)
Also Known as ACADESINE.
CAS: 2627-69-2
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
EINECS: 220-097-5
Melting point : 214-215 °C
Appearance: Off-White Powder .

Product Introduction

Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate).

Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.

Product Usage

A-ICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that A-ICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that A-ICAR can mimic the activity of insul (sc-211647) by activating AM PK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). A-ICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

(AM PK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.A-ICAR is a selective activator of AM PK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.A-ICAR (0.5 mM) inhibits insul-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

Dosage

Dosages range from 150 milligrams (mg) per day (if stacked with GW), up to 500mg a day when used solo. Considering the fact that each bottle typically comes in 50mg dosages, that is quite expensive, as already mentioned above. Economically, it makes most sense to run A-ICAR during the 4 weeks leading up to your competition.

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China GMP Factory Direct Supply 99% Purity Buy a-Icar Acadesine Raw Powder CAS 2627-69-2

Shipment Way

China GMP Factory Direct Supply 99% Purity Buy a-Icar Acadesine Raw Powder CAS 2627-69-2

Research & Development

China GMP Factory Direct Supply 99% Purity Buy a-Icar Acadesine Raw Powder CAS 2627-69-2

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China GMP Factory Direct Supply 99% Purity Buy a-Icar Acadesine Raw Powder CAS 2627-69-2

 

Organic Intermediate

PTSINDIA.NET, 2023