Marya China Syringe Filling Machine with CIP/SIP System Plants
Automatic Grade
Fully Automatic
Material Type
Liquid
Filling Valve Head
Multi-Head
Feed Cylinder Structure
Multi-Room Feeding
Dosing Device
Capacity Cup
Filling Principle
Pressure
Packaging Container Lifting Structure
Pneumatic Lifting
Structure
Linear
Packaging
Bottle
Packaging Material
Plastic
Dimension
1630*1320*1700(mm)
Power Supply
380V 50Hz
Weight
750kg
Power
4.4kw
Transport Package
Wooden Packing
Specification
Standard/Customized
Trademark
Marya
Origin
China
Package Size
350.00cm * 150.00cm * 180.00cm
Package Gross Weight
3500.000kg
Reference Price
$ 81,000.00 - 90,000.00
Description
Product Description
Marya China syringe filling machine with CIP/SIP system plants
As a portable package for a variety of highly active injectable drugs such as innovative biologics, syringes improve the accuracy of medication and make expensive drugs easier to handle. Efficiency and product and protection for operator are essential throughout the filling process, from de-nesting to filling and sealing. We will offer a diverse range of fully automatic syringe filling lines for maximum product safety and process flexibility.
Aseptic prefilled syringe filling and sealing line is mainly used for the unpacking, film tearing, filling and stoppering of disposable syringes, cassette bottles and vial bottles in honeycomb trays in pharmaceutical factories to realize the filling and sealing of pharmaceutical liquid. It is mainly used for the production and packaging of vaccines, monoclonal antibodies, small molecule heparin, insulin, hyaluronic acid and other sterile products.
The use of this production line for the filling and sealing of disposable liquid medicine can reduce the additional filling amount of liquid medicine, and the residual amount of liquid medicine is small when used, which can improve the utilization rate of liquid medicine, so as to effectively reduce the cost. Aseptic prefilled syringe filling and sealing line adopts box-type disposable syringe bottles, cassette bottles and vial bottles, without the need for bottle cleaning and sterilization, so there is no need to configure cleaning machines, dryers and other equipment, which can reduce equipment costs and reduce the risk of pollution. Stopper after filling, the exposure time of the liquid is short, and the pollution risk is small.Vacuum stoppering method can be adopted with less residual air after stoppering, residual amount < 20μL, which may meet the requirements of high oxygen residue of drugs.
This line is used for commercial production in medium and high speed volumes and provides a low-risk, flexible treatment for sterile syringes.
Liquid mixing system
In bioprocessing, we provide flexible support for the production of small and large volume injectable drugs (SVP/LVP) and infusion (IV). Process solutions include modular settings for temperature-controlled stainless steel tanks that can be assembled to meet customer specific settings.
Ready-to-use container upstream processing
Whether you are running low, medium or high speed production lines, safety processes are critical to maintaining product quality. We offer highly automated bag-opening and casing-opening solutions for ready-to-use containers to help you handle pre-filled syringes safely and efficiently. Especially in nested syringe applications, our ABO automatic bag openers and ATO Automatic box openers reduce operator exposure and contamination risks to a low level through fully automated aseptic cleaning.
Filling and sealing
Handling expensive injectable drugs with pre-filled syringes must be extremely caraful and precise. Our full range of filling and sealing systems meet this requirement, with more benefits: a flexible handling system allows the syringe to be gently removed from the tray, further improving filling quality through basic filling weight and stopper position detection. A variety of filling systems, such as peristaltic pumps, increase the hygiene level of the entire process. Exhaust pipe or vacuum stopper ensure tight sealing of syringe.
De-nesting
Our line of pre-filled syringes treats syringes gently from the start. A dedicated handling unit allows the syringe to be precisely removed from the nest box and tray without operator intervention. As a result, a single syringe can be more easily and pollution-freely into the comprehensive inspection station. As experts in the operation of nested syringes, we have developed exclusive solutions for highly automated denesting and safe positioning of pre-filled syringes prior to downstream processing. These devices can be effectively integrated with nesting and detection platforms.
Screw and label
The syringe handling process is not only for filling. Instead, it requires further complex steps: from screwing to attaching a visible, easily identifiable label to the outside. We combine these two steps in a single platform: push rod insertion and labeling applications for glass and plastic (COC) syringes run at high speeds using a screw label machine (RIL), ensuring high quality downstream aseptic processing.
Detection
As with all pharmaceutical containers, pre-filled syringes require a thorough inspection to ensure safety for patients. We have a wide range of manual, semi-automatic and fully automatic testers to check liquid and freeze-dried pharmaceuticals for particle and container defects. Based on deep inspection expertise, we offer cutting-ledge technologies for visual inspection and container seal integrity testing (CCIT), including high pressure leak detection (HVLD), static segmentation (SD) and headspace analysis (HSA). In addition, we offer a fully integrated online inspection solution for multiple inspection tasks, such as container defect detection.
Sterilization
We offer a wide range of sterilization solutions for the efficient handling of porous loads and liquids in open, semi-closed or closed containers. Vacuum steam, steam/air mixture and hot shower processes enable you to achieve repeatable equipment and terminal sterilization processes while optimizing energy requirements.
Syringe filling product portfolio
With decades of experience, we offer you a wide range of flexible syringes, cassette bottles and vial bottle platforms covering both upstream and downstream processes. Our RTU syringe filling machine portfolio includes systems for low, medium and high speed liquid and lyophilized drug production.
Bulk syringe filling
Bulk handling is a challenge in itself: reliable and fast operation is a must for achieving high-speed handling of containers. Bulk syringe equipment offers high accuracy and ease of use: precise feeding of syringe cartridges and variable filling and sealing stations allow for gentle handling of bulk syringes of different sizes.
Automation
Take our data acquisition solution for example: it helps you reliably monitor and record critical process data at the line and container level. SCADA (Monitoring and Data Acquisition) provides real-time data on equipment and processes in a single dashboard, enabling transparent line and batch control. SODA (Single Object Data Acquisition) facilitates supply chain security by managing data from a single container and preventing time - and cost-intensive events such as complaints.
Security and versatility
In terms of process control, sanitary design and isolator integration, we further ensure that our solutions are not only widely versatile, but also guarantee a high level of product safety.
Barrier system
We focus on each component to ensure seamless interaction of secure interfaces among filling machines, isolators and subsequent equipment.
As a portable package for a variety of highly active injectable drugs such as innovative biologics, syringes improve the accuracy of medication and make expensive drugs easier to handle. Efficiency and product and protection for operator are essential throughout the filling process, from de-nesting to filling and sealing. We will offer a diverse range of fully automatic syringe filling lines for maximum product safety and process flexibility.
Aseptic prefilled syringe filling and sealing line is mainly used for the unpacking, film tearing, filling and stoppering of disposable syringes, cassette bottles and vial bottles in honeycomb trays in pharmaceutical factories to realize the filling and sealing of pharmaceutical liquid. It is mainly used for the production and packaging of vaccines, monoclonal antibodies, small molecule heparin, insulin, hyaluronic acid and other sterile products.
The use of this production line for the filling and sealing of disposable liquid medicine can reduce the additional filling amount of liquid medicine, and the residual amount of liquid medicine is small when used, which can improve the utilization rate of liquid medicine, so as to effectively reduce the cost. Aseptic prefilled syringe filling and sealing line adopts box-type disposable syringe bottles, cassette bottles and vial bottles, without the need for bottle cleaning and sterilization, so there is no need to configure cleaning machines, dryers and other equipment, which can reduce equipment costs and reduce the risk of pollution. Stopper after filling, the exposure time of the liquid is short, and the pollution risk is small.Vacuum stoppering method can be adopted with less residual air after stoppering, residual amount < 20μL, which may meet the requirements of high oxygen residue of drugs.
This line is used for commercial production in medium and high speed volumes and provides a low-risk, flexible treatment for sterile syringes.
Liquid mixing system
In bioprocessing, we provide flexible support for the production of small and large volume injectable drugs (SVP/LVP) and infusion (IV). Process solutions include modular settings for temperature-controlled stainless steel tanks that can be assembled to meet customer specific settings.
Ready-to-use container upstream processing
Whether you are running low, medium or high speed production lines, safety processes are critical to maintaining product quality. We offer highly automated bag-opening and casing-opening solutions for ready-to-use containers to help you handle pre-filled syringes safely and efficiently. Especially in nested syringe applications, our ABO automatic bag openers and ATO Automatic box openers reduce operator exposure and contamination risks to a low level through fully automated aseptic cleaning.
Filling and sealing
Handling expensive injectable drugs with pre-filled syringes must be extremely caraful and precise. Our full range of filling and sealing systems meet this requirement, with more benefits: a flexible handling system allows the syringe to be gently removed from the tray, further improving filling quality through basic filling weight and stopper position detection. A variety of filling systems, such as peristaltic pumps, increase the hygiene level of the entire process. Exhaust pipe or vacuum stopper ensure tight sealing of syringe.
De-nesting
Our line of pre-filled syringes treats syringes gently from the start. A dedicated handling unit allows the syringe to be precisely removed from the nest box and tray without operator intervention. As a result, a single syringe can be more easily and pollution-freely into the comprehensive inspection station. As experts in the operation of nested syringes, we have developed exclusive solutions for highly automated denesting and safe positioning of pre-filled syringes prior to downstream processing. These devices can be effectively integrated with nesting and detection platforms.
Screw and label
The syringe handling process is not only for filling. Instead, it requires further complex steps: from screwing to attaching a visible, easily identifiable label to the outside. We combine these two steps in a single platform: push rod insertion and labeling applications for glass and plastic (COC) syringes run at high speeds using a screw label machine (RIL), ensuring high quality downstream aseptic processing.
Detection
As with all pharmaceutical containers, pre-filled syringes require a thorough inspection to ensure safety for patients. We have a wide range of manual, semi-automatic and fully automatic testers to check liquid and freeze-dried pharmaceuticals for particle and container defects. Based on deep inspection expertise, we offer cutting-ledge technologies for visual inspection and container seal integrity testing (CCIT), including high pressure leak detection (HVLD), static segmentation (SD) and headspace analysis (HSA). In addition, we offer a fully integrated online inspection solution for multiple inspection tasks, such as container defect detection.
Sterilization
We offer a wide range of sterilization solutions for the efficient handling of porous loads and liquids in open, semi-closed or closed containers. Vacuum steam, steam/air mixture and hot shower processes enable you to achieve repeatable equipment and terminal sterilization processes while optimizing energy requirements.
Syringe filling product portfolio
With decades of experience, we offer you a wide range of flexible syringes, cassette bottles and vial bottle platforms covering both upstream and downstream processes. Our RTU syringe filling machine portfolio includes systems for low, medium and high speed liquid and lyophilized drug production.
Bulk syringe filling
Bulk handling is a challenge in itself: reliable and fast operation is a must for achieving high-speed handling of containers. Bulk syringe equipment offers high accuracy and ease of use: precise feeding of syringe cartridges and variable filling and sealing stations allow for gentle handling of bulk syringes of different sizes.
Automation
Take our data acquisition solution for example: it helps you reliably monitor and record critical process data at the line and container level. SCADA (Monitoring and Data Acquisition) provides real-time data on equipment and processes in a single dashboard, enabling transparent line and batch control. SODA (Single Object Data Acquisition) facilitates supply chain security by managing data from a single container and preventing time - and cost-intensive events such as complaints.
Security and versatility
In terms of process control, sanitary design and isolator integration, we further ensure that our solutions are not only widely versatile, but also guarantee a high level of product safety.
Barrier system
We focus on each component to ensure seamless interaction of secure interfaces among filling machines, isolators and subsequent equipment.
Filling Machine
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